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. 2014 Dec 29;46(4):219–225. doi: 10.3947/ic.2014.46.4.219

Figure 2.

Figure 2

Plot of ELF/free serum concentration ratios of linezolid considering penetration capacity (constant K) and potential lysis of ELF cells. The modest ratio of linezolid could not be explained with either penetration capacity nor cell lysis. By the difference of the ratios depending on different techniques (linezolid 1, 2 vs. linezolid 3) it was considered that technical errors might be involved in the process of BAL.

Celf, ELF concentration; Cfs, free serum concentration; K, constant K=0.96 + 0.091·ln (partition coefficient · molecular weight-1/2); AUCelf, AUC in ELF; AUCfs, free AUC in serum; ELF, epithelial lining fluid; AUC, area under the curve.