Table 2.

Antibiotic concentrations in ELF and alveolar macrophage cells comparing to serum levels

^aFree serum concentrations or AUCs(area under the curve) were calculated from the protein binding levels of the corresponding antibiotics.

^bC_ELF/C_fs, ratio of antibiotic concentrations in ELF comparing to their free serum levels.

^cAUC_ELF/AUC_fs, ratio of AUC of antibiotic concentrations in ELF comparing to their free serum AUC.

^dC_cell/C_fs, ratio of intracellular antibiotic concentrations comparing to their free serum levels.

^eAUC_cell/AUC_fs, ratio of AUC of intracellular antibiotic concentrations comparing to their free serum AUC.

^fRatios of intracellular concentration to free serum levels were adopted from a study evaluating antibiotic activities in human THP-1 macrophages versus those in culture medium (Reference 14).

^gAUCs were calculated from approximate antibiotic levels retrieved from time-concentration graphs.

ELF, epithelial lining fluid; AUC, area under the curve; BAL, bronchoalveolar lavage; VAP, ventilator associated pneumonia; IV, intravenous; PO, by mouth(per os).