Fig. 1.

A model for the control of hepatic gluconeogenesis by protein arginine methyltransferases (PRMTs). The roles of PRMT1, PRMT4, PRMT5, and PRMT6 in controlling transcriptional activation of gluconeogenic genes and hepatic gluconeogenesis are shown. See the text for detailed information. CRTC2, CREB regulated transcription coactivator 2; FOXO1, forkhead box protein O1; CBP, CREB binding protein; CREB, cAMP response element-binding protein; PGC-1a, peroxisome proliferator-activated receptor γ coactivator 1α; G6Pase, glucose 6-phosphatase; PEPCK, phosphoenolpyruvate carboxykinase.