TABLE 3 ] .
Parameters of Sputum Inflammation According to Number of qPCR Pathogens Found at Baseline
| Parameter | 0 qPCR Positive (n = 28) | 1 qPCR Positive (n = 38) | ≥ 2 qPCR Positive (n = 54) | P Value |
| IL-1β, pg/mL | 45 (30-68) | 111 (55-222) | 169 (100-287) | .01 |
| IL-5, pg/mL | 1.3 (0.7-2.3) | 1.4 (0.9-2.0) | 0.8 (0.5-1.4) | .34 |
| IL-6, pg/mL | 292 (162-527) | 473 (278-806) | 258 (168-395) | .20 |
| IL-8, pg/mL | 3,104 (1,940-4,965) | 3,578 (2,357-5,434) | 3,799 (2,851-5,064) | .77 |
| IL-10, pg/mL | 0.3 (0.2-0.5) | 1.9 (0.9-3.6) | 1.8 (1.0-3.0) | < .01 |
| TNF-α, pg/mL | 2.2 (1.1-4.2) | 5.4 (2.6-1.4) | 8.8 (4.9-15.9) | .02 |
| TNFRI, pg/mL | 843 (573-1,213) | 1,211 (903-1,623) | 1,229 (940-1,608) | .20 |
| CCL2, pg/mL | 605 (426-860) | 697 (482-1,007) | 463 (358-600) | .16 |
| CCL3, pg/mL | 70 (47-105) | 85 (56-128) | 67 (50-90) | .64 |
| CCL4, pg/mL | 957 (607-1,509) | 1,212 (793-1,851) | 858 (574-1,281) | .50 |
| CCL5, pg/mL | 3.2 (1.8-5.7) | 4.7 (3.3-6.9) | 4.2 (3.1-5.5) | .43 |
| CCL13, pg/mL | 47 (31-71) | 37 (27-51) | 21 (14-30) | < .01 |
| CCL17, pg/mL | 33 (20-55) | 31 (22-44) | 18 (12-27) | .07 |
| CXCL10, pg/mL | 404 (260-627) | 334 (211-529) | 207 (142-300) | .07 |
| Log CFU/mL, mean (95% CI) | 6.6 (5.4-7.8) | 7.3 (5.8-9.1) | 7.5 (6.0-9.1) | < .01 |
| Log 16S genome copies/mL, mean (95% CI) | 8.2 (6.8-9.4) | 8.2 (6.1-9.7) | 8.5 (6.8-10.0) | .11 |
| Total cell count, × 106/g | 2.5 (1.9-3.7) | 3.0 (1.9-4.6) | 4.1 (2.8-5.9) | .31 |
| Sputum neutrophils, mean (SEM), % | 64 (4) | 68 (4) | 75 (3) | .06 |
| Sputum neutrophil count, × 106/g | 1.6 (0.9-2.8) | 1.9 (1.1-3.2) | 2.9 (1.9-4.6) | .20 |
| Sputum eosinophils, % | 1.6 (1.1-2.2) | 1.6 (1.0-2.7) | 1.1 (0.8-1.7) | .41 |