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. 2015 Jan 6;8:156. doi: 10.3389/fnana.2014.00156

Figure 1.

Figure 1

Shh expression and lineage during forebrain development. (A) Shh expression in the prechordal plate seen on a transverse section of the head folds of an E8.0 embryo. pm, prechordal mesoderm. (B–D) In situ hybridization detection of Shh on wild type mouse brains. In (C) and (D), the heads have been saggitally halved to show the neuroepithelium-ventricular zone on the inner side of the brain; rostral to the left. (B) Continuous Shh expression domain in the ventral forebrain at E9.0. (C) Shh expression is downregulated in the basal hypothalamus at E9.5–E10.0. (D) Shh hypothalamic expression at E12.5. (E–G) Diagrams of Shh (black) and Gli1 (pink) expression domains in the presumptive hypothalamus at three embryonic ages (only two for Gli1), together with their progeny represented in schemas of transverse sections through the hypothalamus (middle, blue in (F); late, yellow in (G)). (Right side panels in (F), (G), are from Alvarez-Bolado et al., 2012). Abbreviations: ARH, arcuate nucleus; DMH, dorsomedial nucleus; LH, lateral hypothalamic area; ME, median eminence; mth, mammillothalamic tract; ne, neuroectoderm; nf, neural folds; nt, neural tube; pm, prechordal mesoderm; VMH, ventromedial nucleus.