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. 2015 Jan 6;8:441. doi: 10.3389/fncel.2014.00441

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Copyright © 2015 Lucas, Reid, McMeekin, Dougherty, Floyd and Cowell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ataxia characterized by altered gait kinematics in mice lacking PGC-1α. CatWalk gait analysis was performed on male PGC-1α^+/+ and ^−/− littermates at 6 months of age. PGC-1α^−/− mice exhibited decreased hindpaw area (A), increased hindpaw stand index (B), decreased forepaw and hindpaw swing speed (C), and an increased number of missteps (D) compared to their littermate controls. Representative digitized paw prints and associated step cycles are shown in (E) with RF, right front paw, RH, right hind paw, LF, left front paw, and LH, left hind paw. Two-tailed t-tests. ^*p < 0.05, ^**p < 0.005. n/group indicated on last bar histogram. Data are presented as mean ± SEM.