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. 2015 Jan 6;8:441. doi: 10.3389/fncel.2014.00441

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Copyright © 2015 Lucas, Reid, McMeekin, Dougherty, Floyd and Cowell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Novel cerebellar PGC-1α-dependent genes. q-RT-PCR of microarray-identified PGC-1α regulated transcripts was performed on cerebellar homogenates from PGC-1α^+/+, ^+/−, and ^−/− littermates at 30 days of age. Expression of transcripts spanning synaptic (Cplx1, Pacsin2; (A), structural [Nefh; (B)], and metabolic [Idh3a, Nceh1, Pdha1, Phyh, Uqcrfs1; (C)] functions were significantly decreased in PGC-1α^−/− compared to littermate control cerebella. One-Way ANOVA followed by Fisher's LSD. ^*p < 0.05, ^**p < 0.005, ^***p < 0.0005. n/group indicated on last bar histogram. Data are presented as mean ± SEM.