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. 2014 Jun 18;5(6):747–763. doi: 10.1002/wrna.1244

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© 2014 The Authors. WIREs RNA published by John Wiley & Sons, Ltd.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Fig 2 — Initiation of translation. Messenger RNA (mRNA) translation begins after export, with association with translation initiation factors including eIF4E, eIF4G, and Pab1p. Translation initiation begins with the formation of the 43S preinitiation complex consisting of the small ribosomal subunit (40S), methionyl tRNA, and additional initiation factors. The preinitiation complex binds to the mRNA to form a 48S complex. The small ribosomal subunit then scans the message in the 5′→3′ direction until it recognizes an AUG codon. In association with other initiation factors, the large ribosomal subunit (60S) forms an 80S complex, which commences translation.