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Intrinsic inhibition of translation and messenger RNA (mRNA) stability. Intrinsic inhibition of translation directly or indirectly inhibits initiation on specific messages. Subsequent to inhibition, mRNA is freed from ribosomes as they translocate off the mRNA. Decapping activators assemble on mRNA, predominantly at the 3′ UTR, and recruit the decapping enzyme. mRNA is decapped and degraded by Xrn1p in the 5′→3′ direction.
