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Co-translational messenger RNA (mRNA) decay. A translating mRNA is decapped by the Dcp1/2 decapping complex. Once the 5′ 7-methyl-guanosine cap is removed by the decapping enzyme, 5′→3′ exonucleolytic decay mediated by the exonuclease Xrn1p proceeds. During decay, the ribosomes block the exonuclease until they translocate off the mRNA.
