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Dhh1p-mediated inhibition of ribosomal translocation. A translating messenger RNA (mRNA) directly or indirectly recruits Dhh1p. Once associated with an mRNA, Dhh1p acts to inhibit elongation of the message by the ribosomes. The affected mRNA can then undergo one of three fate choices: 5′→3′ degradation by decapping and exonucleolytic decay, storage in P bodies, or other structures or accumulation of translationally slowed ribosomes.
