Fig. 7. Chemo-enzymatic total syntheses of alkaloids published per year. The colours indicate the different chemo-enzymatic approaches as discussed in this review: (a) biocatalytic preparation of chiral building blocks (blue), (b) biocatalytic kinetic resolution, desymmetrisation, and deracemisation of alkaloids (green), and (c) chemo-enzymatic syntheses that use enzymes for key asymmetric C–C and/or C–N bond formation (orange).