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. 2013 Aug 7;3(39):17602–17632. doi: 10.1039/c3ra42123f

Scheme 30. Application of norcoclaurine synthase in the asymmetric synthesis of tetrahydroisoquinolines: (a) one-pot chemo-enzymatic synthesis of (S)-norcoclaurine (234) using NCS from Thalictrum flavum, (b) non-natural tetrahydroisoquinolines 239–242 prepared using NCS from Coptis japonica.

Scheme 30