Figure 1.

Mechanisms of donor-specific antibody-mediated endothelial injury in renal allografts. Anti-MHC antibodies may either result in direct injury to the capillary endothelium or in indirect injury via complement fixation or recruitment of inflammatory cells with Fc receptors. In cases with donor-specific antibodies that lack C4d deposition, endothelial injury and cellular recruitment could be important mediators. Poly, polymorphonuclear cell. Reproduced with permission from Farkash and Colvin ¹⁵.