Hematology and laboratory parameters at month 35 postrandomization (extension study population)
| CNI-free (n = 41) | CNI (n = 40) | p-Value | |
|---|---|---|---|
| Hematology, mean (SD) | |||
| White blood cell count, 109/L | 6.3 (2.3) | 6.5 (2.3) | 0.826 |
| Platelets, 109/L | 201 (86) | 186 (65) | 0.349 |
| Neutrophils, % | 61 (12) | 65 (10) | 0.189 |
| Hemoglobin, g/dL | 13.2 (1.6) | 14.0 (1.6) | 0.061 |
| Liver function | |||
| Aspartate transaminase (ASAT), U/L | |||
| Mean (SD) | 32 (13) | 44 (37) | 0.090 |
| Median (range) | 31 (14–71) | 27 (11–129) | – |
| Alanine transaminase (ALAT), U/L | |||
| Mean (SD) | 32 (9) | 46 (43) | 0.061 |
| Median (range) | 33 (17–49) | 27 (11–195) | – |
| Gamma-glutamyl transferase | |||
| Mean (SD) | 50 (71) | 89 (143) | 0.168 |
| Median (range) | 28 (0.4–367) | 47 (7–717) | – |
| Total bilirubin, µmol/L | |||
| Mean (SD) | 7.7 (4.4) | 15.8 (19.4) | 0.023 |
| Median (range) | 6.8 (3.0–23.9) | 10.3 (5.1–109.4) | – |
| Metabolic, mean (SD) | |||
| Total cholesterol, mmol/L | 5.6 (1.2) | 4.8 (1.0) | 0.006 |
| LDL-cholesterol, mmol/L | 3.2 (0.9) | 2.9 (0.8) | 0.293 |
| HDL-cholesterol, mmol/L | 1.5 (0.5) | 1.3 (0.5) | 0.446 |
| Triglycerides, mmol/L | 2.4 (1.7) | 1.7 (1.1) | 0.076 |
Values are shown as mean (SD).
Table 1t-Test (between-group comparison).
CNI, calcineurin inhibitor; HDL, high-density lipoprotein; LDL, low-density lipoprotein; SD, standard deviation.