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. 2015 Jan;21(1):136–141. doi: 10.3201/eid2101.141006

Table 2. Characteristics of patients infected with oseltamivir-resistant and -susceptible A(H1N1)pdm09 viruses, United States, October 1, 2013–April 30, 2014*.

Characteristic Patients with oseltamivir-resistant infections, n = 49† Patients with oseltamivir-susceptible infections, n = 93† p value OR (95% CI)
Median age, y (IQR) 25 (14–53) 24 (18–46) 0.86 NA
Male sex 22/49 (45) 37/92 (40) 0.59 1.21 (0.59–2.46)
White race 32/47 (68) 64/88 (73) 0.84 0.73 (0.37–1.89)
Exposure to oseltamivir before specimen collection 15/49 (31) 9/93 (10) 0.002 4.12 (1.65–10.31)
Outpatients 2/32 (6.3) 1/65 (1.5) 0.21 4.27 (0.37–48.9)
Hospitalized patients 13/17 (76) 8/27 (30) 0.003 7.72 (1.92–31.06)
Exposure to others in household receiving antiviral drugs before patient’s illness 5/33 (15) 4/62 (6) 0.16 2.64 (0.63–11.07)
Any underlying medical conditions 25/49 (51) 50/93 (54) 0.8 0.85 (0.39–1.86)
Chronic pulmonary disease 5/49 (10) 7/93 (8) 0.59 1.2 (0.28–5.07)
Chronic cardiac disease 6/49 (12) 10/93 (11) 0.79 1.38 (0.39–4.83)
Diabetes mellitus 6/49 (12) 8/93 (9) 0.49 1.82 (0.53–6.26)
Immunosuppressive conditions‡ 8/49 (16) 6/93 (7) 0.07 3.2 (0.1–10.3)
Other§ 9/49 (18) 23/93 (25) 0.39 0.66 (0.27–1.61)
Hospitalized during influenza illness 17/49 (35) 27/92 (29) 0.51 1.51 (0.67–3.43)
Patient died 7/47 (15) 6/93 (6) 0.1 2.8 (0.86–9.14)
Others in the household were ill before patient’s illness 12/32 (38) 21/65 (32) 0.61 1.2 (0.47–3.05)

*OR, odds ratio adjusted for age group; IQR, interquartile range; NA, not applicable.
†Values are no./total (%) unless otherwise indicated.
‡Long history of steroids treatment, HIV/AIDS, solid organ transplant, lupus, solid tumor malignancy, hypothyroidism, leukemia, and pituitary condition.
§Morbid obesity, chronic liver disease, neurologic disorders, chronic kidney disease, seizure, epilepsy, and depression.