Table 2. Characteristics of patients infected with oseltamivir-resistant and -susceptible A(H1N1)pdm09 viruses, United States, October 1, 2013–April 30, 2014*.
Characteristic | Patients with oseltamivir-resistant infections, n = 49† | Patients with oseltamivir-susceptible infections, n = 93† | p value | OR (95% CI) |
---|---|---|---|---|
Median age, y (IQR) | 25 (14–53) | 24 (18–46) | 0.86 | NA |
Male sex | 22/49 (45) | 37/92 (40) | 0.59 | 1.21 (0.59–2.46) |
White race | 32/47 (68) | 64/88 (73) | 0.84 | 0.73 (0.37–1.89) |
Exposure to oseltamivir before specimen collection | 15/49 (31) | 9/93 (10) | 0.002 | 4.12 (1.65–10.31) |
Outpatients | 2/32 (6.3) | 1/65 (1.5) | 0.21 | 4.27 (0.37–48.9) |
Hospitalized patients | 13/17 (76) | 8/27 (30) | 0.003 | 7.72 (1.92–31.06) |
Exposure to others in household receiving antiviral drugs before patient’s illness | 5/33 (15) | 4/62 (6) | 0.16 | 2.64 (0.63–11.07) |
Any underlying medical conditions | 25/49 (51) | 50/93 (54) | 0.8 | 0.85 (0.39–1.86) |
Chronic pulmonary disease | 5/49 (10) | 7/93 (8) | 0.59 | 1.2 (0.28–5.07) |
Chronic cardiac disease | 6/49 (12) | 10/93 (11) | 0.79 | 1.38 (0.39–4.83) |
Diabetes mellitus | 6/49 (12) | 8/93 (9) | 0.49 | 1.82 (0.53–6.26) |
Immunosuppressive conditions‡ | 8/49 (16) | 6/93 (7) | 0.07 | 3.2 (0.1–10.3) |
Other§ | 9/49 (18) | 23/93 (25) | 0.39 | 0.66 (0.27–1.61) |
Hospitalized during influenza illness | 17/49 (35) | 27/92 (29) | 0.51 | 1.51 (0.67–3.43) |
Patient died | 7/47 (15) | 6/93 (6) | 0.1 | 2.8 (0.86–9.14) |
Others in the household were ill before patient’s illness | 12/32 (38) | 21/65 (32) | 0.61 | 1.2 (0.47–3.05) |
*OR, odds ratio adjusted for age group; IQR, interquartile range; NA, not applicable. †Values are no./total (%) unless otherwise indicated. ‡Long history of steroids treatment, HIV/AIDS, solid organ transplant, lupus, solid tumor malignancy, hypothyroidism, leukemia, and pituitary condition. §Morbid obesity, chronic liver disease, neurologic disorders, chronic kidney disease, seizure, epilepsy, and depression.