Table 1. Antimicrobial drug susceptibility of Burkholderia pseudomallei and B. thailandensis strains from Gabon, 2012–2013*.
| Drug | MIC,
mg/L |
|||
|---|---|---|---|---|
| Break point resistance | B. pseudomallei patient strain | B. pseudomallei soil strain C2 | B. thailandensis soil strain D50 | |
| Amikacin | 4† | 96 | 96 | 128 |
| Tobramycin | 4† | 16 | 24 | 24 |
| Ciprofloxacin | 1 | 0.75 | 1.0 | 0.5 |
| Moxifloxacin | 1‡ | 0.75 | 0.75 | 0.75 |
| Meropenem | 4 | 0.75 | 0.75 | 0.75 |
| Ceftazidime | 8 | 2 | 2 | 2 |
| TMP/SMX | 1/19 | 1 | 1 | 1 |
| AMC | 8/2 | 4 | 4 | 6 |
| TZP | 32/?§ | 1.5 | 1.5 | 3 |
| Chloramphenicol | 8 | 3 | 3 | 3 |
| Tetracycline | 4¶ | 1.5 | 2 | 8 |
| Polymyxin B | NA# | >1,024 | >1,024 | >1,024 |
*Bacterial isolates were tested for their susceptibility to antimicrobial agents. MIC (MICs; mg/L) were determined by E-test on Mueller-Hinton-agar. When available break points were defined as described [19]. AMC, amoxicillin/clavulanic acid; NA, not applicable; TMP/SMX, trimethoprim/sulfamethoxazole, TZP, piperacillin/ tazobactam. †Break point for gentamicin was used. ‡Break point for ciprofloxacin was used. §Break point available for piperacillin only. ¶Break point for doxycycline was used. #Intrinsic resistance.