Table 1. Clinical features of Burkholderia pseudomallei strains isolated from patients with neurologic and nonneurologic melioidosis and their virulence in C57BL/6 and BALB/c mice, Northern Territory, Australia, October 1989–October 2012*.
MSHR ID no. | Age, y/sex | Clinical feature | Risk factor | ID50 in mice (CFU)† |
||||
---|---|---|---|---|---|---|---|---|
Intranasal |
Subcutaneous |
|||||||
C57BL/6 | BALB/c | C57BL/6 | BALB/c | |||||
Neurologic | ||||||||
668‡ | 53/M | Severe neurologic signs | None | 4.1 × 104 | 2.9 × 102 | 7.1 × 103 | <10 | |
305§ | 64/M | Severe neurologic signs | Alcohol use | 2.6 × 102 | 2.6 × 102 | 3.7 × 104 | <10 | |
62‡ | 24/M | Severe neurologic signs | None | 2.2 × 102 | 6.3 × 101 | 2.4 × 102 | <10 | |
435‡ | 37/M | Severe neurologic signs | Kava | 5.0 × 102 | 1.3 × 102 | <10 | <10 | |
1153§ | 60/M | Severe neurologic signs | Diabetes mellitus | 1.7 | <10 | <10 | <10 | |
3709‡ |
14/M |
Moderate neurologic signs |
None |
4.4 × 104 |
1.8 × 104 |
|
2.2 × 102 |
1.3 × 102 |
Nonneurologic | ||||||||
1655‡ | 61/F | Chronic pulmonary | Bronchiectasis | >108 | >108 | >2 × 108 | >2 × 108 | |
465§ | 67/M | Septicemia | Diabetes mellitus, chronic obstructive pulmonary disease | 1.3 × 105 | 1.1 × 103 | 8.3 × 105 | <10 | |
2138‡ | 49/F | Septicemia | Diabetes mellitus | 3.6 × 103 | <10 | 4.2 × 103 | 1.2 × 101 | |
346‡ | 49/M | Chronic pulmonary | Alcohol use | 8.5 × 104 | 6.0 × 104 | 6.0 × 105 | 7.0 × 105 | |
543‡ | 22/F | Skin ulcer | None | 2.9 × 102 | 8.5 × 101 | 1.2 × 101 | <10 |
*ID50, 50% infectious dose; MSHR ID, neurologic isolate identification. †ID50 determined after intranasal and subcutaneous infection of C57BL/6 and BALB/c mice ‡Nonfatal. §Fatal.