Table 2.
Thrombin generation in human platelet-poor plasma spiked with rivaroxaban, melagatran, or dabigatran without and with thrombomodulin
| Parameter | Rivaroxaban | Melagatran | Dabigatran | |||
|---|---|---|---|---|---|---|
| −TM | +TM | −TM | +TM | −TM | +TM | |
| Cmax IC50 (nmol L−1) | 66 ± 5 | 44 ± 6 | 940 ± 79 | >950 | 976 ± 71 | >1090 |
| ETP IC50 (nmol L−1) | 697 ± 106 | 57 ± 8 | 732 ± 43 | >950 | 722 ± 44 | >1090 |
Results are shown as mean ± standard error of the mean; n = 8–12 in normal plasma from healthy volunteers.
Cmax, peak thrombin generation; ETP, endogenous thrombin potential; IC50, maximal drug concentration to cause 50% inhibition; TM, thrombomodulin.