Table 3.

Purity evaluation of C1-INH concentrates

Content	Purity defined as AUC (% of total AUC)
	Berinert	Cetor	Cinryze	Ruconest
High-molecular-weight proteins, mean	2.8	11.0	10.2	0.6
Batch 1	2.8	11.0	12.2	0.6
Batch 2	2.8	NA	8.2	0.6
C1-INH protein, mean (standard method)*	94.7	67.4	69.6	98.6
Batch 1	94.6	67.4	71.3	98.6
Batch 2	94.9	NA	68.0	98.6
C1-INH protein, mean (adapted method)†	97.0	88.6	89.5	98.6
Batch 1	97.0	88.6	87.6	98.6
Batch 2	97.0	NA	91.5	98.6
Low-molecular-weight proteins, mean	0.2	0.3	0.3	0.8
Batch 1	0.2	0.3	0.2	0.8
Batch 2	0.2	NA	0.3	0.8

^*Amount of C1-INH protein evaluated with the standard Berinert method at an elution time of 13.5 to 15.0 minutes.

^†Amount of C1-INH protein evaluated with the adapted Berinert method to cover peak split in Cetor and Cinryze at an elution time of 13.5 to 17.0 minutes.