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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Bone. 2014 Nov 22;72:81–91. doi: 10.1016/j.bone.2014.11.010

Figure 4. Regulation of gene expression by PTH and 1,25(OH)2D3 is highly correlated.

Figure 4

(A) Venn diagram of PTH-regulated (100nM PTH vs vehicle, 24 hr treatment) and 1,25(OH)2D3-regulated (100nM 1,25(OH)2D3 vs vehicle, 24 hr treatment) genes. Genes in both cohorts are classified as regulated if their gene expression levels are affected ≥ 2 fold, 95% confidence interval, moderated t test. (B) Top GO term from the top 3 annotation clusters with associated P values from DAVID GO term analysis for gene groups from part (A). (C) Genes from (A) were clustered using the Euclidian distance metric and visualized as a heatmap. (D) Venn diagram of PTH (purple) and 1,25(OH)2D3 (green) up- and down- regulated genes.