Skip to main content
. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Bone. 2014 Nov 22;72:81–91. doi: 10.1016/j.bone.2014.11.010

Figure 6. pCREB and VDR exhibit overlapping cistromes.

Figure 6

A) 17496 forskolin-induced pCREB binding sites in MC3T3-E1 cells were compared to 2969 1,25(OH)2D3-induced VDR binding sites in IDG-SW3 d35 cells. 1080 sites overlapped and these were associated with 1485 genes through the GREAT algorithm. 46 of the 444 genes associated with the PTH- and 1,25(OH)2D3-regulated transcriptome in IDG-SW3 osteocytes (24 hr at 100nM PTH or 1,25(OH)2D3 vs vehicle, ≥ 2 fold, 95% confidence interval, moderated t test) were among the associated genes. B) ChIP-seq tag density tracks (normalized to 107 tags) for pCREB binding in MC3T3-E1 preosteoblasts and VDR binding in IDG-SW3 d35 osteocytes at the gene locus for Edar.