Table 1.
Blood pressure and heart rate parameters for OxyVita C, Hextend (HEX), and saline (0.9% NaCl) groups. All values are means ± SD. * Post-infusion value (T30, T70, T110 or T150) is significantly different (P ≤ 0.05) from its corresponding within-group value at T0; values at pre-infusion times T40, T80, and T120 were not compared to T0. # Post-infusion value (T30, T70, T110 or T150) is significantly different (P ≤ 0.05) from its corresponding within-group value at the preceding pre-infusion timepoint (T0, T40, T80, or T120). Significant differences (P ≤ 0.05) between treatment groups at each timepoint are indicated by similar superscripted letters (a or b).
| Time | Treatment | SBP (mm Hg) | MAP (mm Hg) | DBP (mm Hg) | HR (beats/min) |
|---|---|---|---|---|---|
| T0 (Pre-treatment) | OxyVita C | 124.6 ± 14.8 | 98.3 ± 10.7 | 82.3 ± 9.6 | 385.8 ± 76.3 a |
| 0.9% NaCl | 118.7 ± 15.5 | 93.5 ± 13.0 | 78.5 ± 11.8 | 304.5 ± 61.3 a,b | |
| HEX | 128.7 ± 11.0 | 99.4 ± 8.6 | 81.7 ± 9.9 | 391.6 ± 73.8 b | |
| T30 (After infusion 1) | OxyVita C | 134.6 ± 14.8 #,a | 107.4 ± 9.7 #,a,b | 90.4 ±7.9 | 392.9 ± 72.8 a |
| 0.9% NaCl | 120.9 ± 8.2 a | 92.5 ± 7.4 a | 76.5 ± 7.6 | 308.3 ± 41.9 a,b | |
| HEX | 129.8 ± 10.9 | 99.1 ± 7.2 b | 80.7 ± 8.6 | 367.0 ± 79.2 b | |
| T40 (Before infusion 2) | OxyVita C | 125.1 ± 11.7 | 99.5 ± 8.2 | 84.1 ± 8.2 | 388.5 ± 90.0 |
| 0.9% NaCl | 121.7 ± 13.5 | 95.2 ± 11.5 | 79.0 ± 11.1 | 338.0 ± 35.8 | |
| HEX | 125.5 ± 13.2 | 97.5 ± 11.3 | 79.7 ± 12.5 | 349.8 ± 89.4 | |
| T70 (After infusion 2) | OxyVita C | 130.6 ± 13.6 # | 102.9 ± 10.8 | 84.8 ± 10.3 | 383.5 ± 78.9 |
| 0.9% NaCl | 121.1 ± 13.6 | 92.0 ± 12.6 | 76.7 ± 12.0 | 318.1 ± 43.7 | |
| HEX | 132.5 ± 12.0 | 102.5 ± 7.0 | 85.0 ± 4.8 | 363.6 ± 79.4 | |
| T80 (Before infusion 3) | OxyVita C | 128.7 ± 12.1 | 100.7± 10.9 a | 83.9 ± 10.2 | 387.3 ± 97.1 |
| 0.9% NaCl | 119.0 ± 17.8 | 92.6 ± 17.5 a,b | 76.8 ± 16.5 | 335.8 ± 65.4 | |
| HEX | 128.1 ± 9.4 | 98.8 ± 6.2 b | 81.4 ± 5.9 | 377.7 ± 72.5 | |
| T110 (After infusion 3) | OxyVita C | 134.6 ± 13.6 # | 107.1 ± 13.2 #,a | 90.1 ± 13.5 | 388.1 ± 98.9 |
| 0.9% NaCl | 123.7 ± 16.7 | 94.3 ± 17.8 a | 78.8 ± 17.3 | 331.0 ± 44.6 * | |
| HEX | 132.1 ± 12.5 | 101.6 ± 9.8 | 83.5 ± 7.3 | 387.7 ± 76.6 | |
| T120 (Before infusion 4) | OxyVita C | 136.3 ± 12.7 | 108.6 ± 11.4 | 91.6 ± 11.1 | 382.1 ± 87.2 |
| 0.9% NaCl | 118.3 ± 17.5 | 91.5 ± 16.0 | 75.3 ± 15.6 | 351.2 ± 47.9 | |
| HEX | 131.8 ± 16.9 | 100.9 ± 12.9 | 83.3 ± 10.8 | 370.7 ± 73.8 | |
| T150 (After infusion 4) | OxyVita C | 143.9 ± 14.4 #,*,a | 116.3 ± 14.5 #,*,a,b | 98.9 ± 14.4 | 386.3 ± 84.8 |
| 0.9% NaCl | 124.6 ± 12.6 a | 93.5 ± 14.5 a | 77.1 ± 14.3 | 324.7 ± 56.5 | |
| HEX | 135.4 ± 15.3 | 103.0 ± 9.3 b | 84.8 ± 7.0 | 363.5 ± 68.3 |