TABLE 1.

Clinical reports of epidermal maturation arrest

PATIENT DESCRIPTION	PROCEDURE, DIAGNOSIS AND LOCATION	INITIAL DEFECT SIZE	FOLLOW-UP #1	TREATMENT #1	FOLLOW-UP #2	TREATMENT #2	FOLLOW-UP #3	TREATMENT #3	FINAL OUTCOME
38-year-old female6	Status-post MOHs on left temple for basal cell carcinoma arising in sebaceous nevus	8.5 x 2.5cm	At 6 weeks post- operatively: Defect: 7.8 x 2.0cm; Granulation tissue appeared glossy; Biopsy showed granulation tissue	Silver nitrate and biological dressings	At 10 weeks post- operatively: No change in granulation tissue	Silver nitrate and multiple biologic dressings	At 6 months post- operatively: Defect: 6.2 x 1.6cm; Repeat biopsy showed granulation tissue	Six weeks of temovate gel to remaining defect	After 6 weeks of temovate gel, the final defect measured 1cm
44-year-old male6	Status-post MOHs on left forehead and scalp for basal cell carcinoma and squamous cell carcinoma	12.5 x 7.4cm	At 3 weeks post- operatively: Defect: 12.2 x 7.4cm; Granulation tissue appeared glossy	Silver nitrate applied to foci of over- granulation	At 8 weeks post- operatively: Defect: 12.0 x 6.7cm; Granulation tissue unchanged	Temovate ointment under occlusion until 10 weeks post- operatively	At 12 weeks post- operatively: Defect: 10 x 5.8cm	Four weeks of ibuprofen 200mg po TID	At 16 weeks post- operatively: Few focal erosions remaining; At 6 months post- operatively: Healing complete
59-year-old male6	Status-post MOHS to right cheek for recurrent basal cell carcinoma	6.5 x 6.0cm	At 3 weeks post- operatively: Defect: 5.2 x 4.0cm	Not specified	At 3 months post- operatively: Defect: 2.5 x 1.7cm; Granulation tissue with glossy appearance	Ibuprofen po BID with nonstick wound dressings	After 2 weeks of ibuprofen po BID, the defect had re-epithelialized	NA	Two weeks of NSAIDs brought about completed re-epithelialization; topical steroids not applied at all
80-year-old Caucasian female6	Donor SPSG site from the thigh to close MOHS on the right cheek	SPSG site on the thigh: 7.8 x 5.4cm	At 3 weeks post-operatively: defect appeared hypergranulated	Silver nitrate	At 6 weeks post-operatively: Small area of mature epidermis on lower half of defect	Silver nitrate and ibuprofen 200mg po BID	At 12 weeks post-operatively: Defect: 2 x 1cm	Ibuprofen discontinued and halobetasol proprionate ointment applied	At 15 weeks post-operatively: Re-epithelialization complete
76-year-old female8	Status-post laser vaporization for Bowen’s disease on the frontal scalp in two parts; each half of the lesion treated and separated by 6 months	Defect after treatment not specified Silver nitrate applied for unspecified time	At 6 months post-operatively: Granulation tissue persisted; Biopsy showed erosion with edema of papillary dermis and mixed perivascular infiltrate	At 9 months post-operatively: Diflorasone ointment prescribed	At 10 months post-operatively: Re-epithelialization was complete	NA	NA	NA	After 1 month of applying diflorasone ointment, epithelialization was complete