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. Author manuscript; available in PMC: 2015 Jan 6.
Published in final edited form as: Control Clin Trials. 2004 Apr;25(2):178–202. doi: 10.1016/j.cct.2003.08.014

Table 3.

Effect sizes detected for primary endpointsa

Variable S.D. Placebo vs.
active drug:
effect size
detected		 Fraction of
S.D. for
active drug
vs. placebo		 Simva vs.
Prava:
effect size
detected		 Fraction of
S.D. detected
for Simva vs.
Prava
Behaviorb
PSAP (aggressions/min) 1.29 0.32 0.247 0.37 0.285
Cognitive functionc
Digit vigilance (errors) 04.6 1.36 0.30 1.57 0.34
Recurrent words (% hits) 13.2 3.89 0.30 4.51 0.34
Maze completion (s) 41.0 12.1 0.30 14.0 0.34
Pegboard time (s) 14.2 4.19 0.30 4.86 0.34
Serotonin (5HT)d
Whole blood 5HT (ng/ml) 65.0 16.1 0.247 18.5 0.285

S.D.=standard deviation; Simva=simvastatin; Prava=pravastatin; min=minute; s=seconds; 5HT=5-hydroxytryptamine (serotonin).

a

Alpha=0.05, two-sided; power of 0.9; n=1000.

b

Data from Dr. D. Cherek.

c

Data from Dr. M. Muldoon.

d

Data from Moffitt et al. [61].