Figure 1.

Western blot data showing that knock-down of STAT3 results in downregulation of β-catenin but not vice versa. (a) This was a reproducible effect seen in six different colorectal cancer cell lines. (b) This shows the effect of STAT3 knock-down, when tested in a further three colorectal cancer cell lines, was a reduction in β-catenin levels. (c) shows that forced expression of dominant-negative TCF4 (DN-TCF4) caused downregulation of c-Myc but had no effect on STAT3 when compared to empty vector (EV).