Table 1.

Outstanding questions for preventing airway infection in primary antibody deficiency

Outstanding questions for preventing airway infection in primary antibody deficiency Which immunoglobulin (Ig) isotype would be the most feasible therapy for the management of airway disease? How to transport Ig effectively to the site which includes difficult-to-reach areas, such as the paranasal sinuses and the terminal bronchioli? Would IgG or monomeric IgA therapy result in a more fierce inflammatory response at the airway epithelium once it binds to pathogens?