TABLE 1.
Assessment of AHR in WT and Htr4−/− mice
| Parameter | Broncho-constrictor | PC200/PC50 mg/ml (WT) | PC200/PC50 mg/ml (Htr4−/−) | Percent change |
|---|---|---|---|---|
| Resistance (R) | MCH | 15.2 | 11.1 | −27% |
| Tissue resistance (G) | MCH | 14.8 | 7.74 | −48% |
| Tissue elastance (H) | MCH | 35.5 | 25.0 | −30% |
| Resistance (R) | 5-HT | 61.6 | 29.5 | −52% |
| Newtonian resistance (Rn) | 5-HT | 37.9 | 27.3 | −28% |
| Tissue resistance (G) | 5-HT | 107 | 39.3 | −63% |
| Compliance (C) | 5-HT | 42.4 | 21.7 | −49% |
| Elastance (E) | 5-HT | 31.0 | 8.54 | −72% |
PC200 or PC50 was calculated as the concentration needed to increase baseline parameters by 200% (for R, Rn, G, and H) or decrease baseline parameter by 50% (for C).