Table 5.
Association Between Risk Factors and Chronic Drug-Induced Livery Injury Based on Logistic Regression
| Parameter | Univariate probability model
|
Multivariate logistic regression probability model C-statistic = 0.71 (95% CI: 0.65–0.76)
|
||
|---|---|---|---|---|
| Odds ratio (95% CI) | P value | Odds ratio (95% CI) | P value | |
| Female | 1.49 (0.97–2.30) | .07 | ||
| Race | ||||
| White | Reference | |||
| Black | 2.42 (1.360–4.29) | <.01 | 3.10 (1.68–5.72) | <.01 |
| Asian | 2.42 (0.81–7.25) | .12 | 3.12 (0.95–10.22) | .06 |
| Other | 0.62 (0.21–1.81) | .39 | 0.82 (0.28–2.43) | .72 |
| Malignancy | ||||
| No malignancy | Reference | |||
| Inactive malignancy | 1.30 (0.51–3.29) | .58 | 1.34 (0.47–3.83) | .72 |
| Active malignancy | 5.19 (2.22–12.1) | <.01 | 6.37 (2.59–15.7) | <.01 |
| Duration of primary agent use | 1.0 (1.0–1.001) | .06 | ||
| ALP at onset, unit = 50 U/L | 1.07 (1.03–1.11) | <.01 | 1.08 (1.04–1.12) | <.01 |
| Total bilirubin at onset, mg/dL | 1.03 (0.999–1.06) | .06 | ||
| Hemoglobin at onset (±14 days) | 0.83 (0.73–0.95) | <.01 | ||
| Albumin at onset (±14 days)a | 0.64 (0.47–0.86) | <.01 | ||
| Heart disease | ||||
| No heart disease | Reference | |||
| Inactive heart disease | 3.53 (1.50–8.32) | <.01 | 3.36 (1.35–8.39) | <.01 |
| Active heart disease | 1.01 (0.57–1.80) | .96 | 0.77 (0.40–1.49) | .44 |
NOTE. Predictors based on demographic and clinical information at onset or baseline selected by clinical judgment, univariate logistic regression with P value <.10, and with <50% missing data. Odds ratio should be interpreted based on 1-unit increase unless otherwise indicated with a magnitude of unit increase. “Malignancy” refers to lifetime history of cancer and “active malignancy” delineates the subgroup of patients with a malignancy requiring treatment at the time of DILI onset. Similarly, “heart disease” refers to lifetime history of cardiac disease and “active heart disease” refers to subjects with a cardiac condition requiring treatment at the time of DILI onset.