Table 3.

Comparison of genotype frequencies between ramosetron responders and non-responders

	Allele frequencies pa for HWE	Genotype	Ramosetron Non-responders n=16	Ramosetron responders n=26	p values
SLC6A4 5-HTTLPR del(s)/ins(l)	l=0.18, s=0.82 p=0.38	ll/ls/ss ss (%)	0/8/8 50	0/7/19 73.1	0.13
SLC6A4 intron 2 VNTR	10rep=0.12 12rep=0.88 p =0.69	10/12 & 12/12rep	2/14	8/18	0.27
TPH1 rs4537731 −1066 T > C	T=0.87, C=0.13 p =0.93	TT/TC/CC C allele %	8/7/1 50	24/2/0 11.5	0.003
TPH1 rs7130929 −347 C > A	C=0.87, A=0.13 p =0.93	CC/CA/AA A allele %	8/7/1 50	24/2/0 11.5	0.003
TPH1 rs684302 7465 C > T	C=0.42, T=0.68 p =0.34	CC/CT/TT C allele %	2/7/7 56.2	3/10/13 50	0.69
TPH1 rs211105 12517 T > G	T=0.89, G=0.11 p =0.58	TT/GT/GG G allele %	9/6/1 43.8	25/1/0 3.8	0.003
TPH1 rs1800532 218 G>T	G=0.33, T=0.67 p =0.66	GG/GT/TT T allele %	3/6/7 56.2	13/10/3 50	0.69
TPH1 rs1799913 779 G > T	G=0.32, T=0.68, p =0.90	GG/GT/TT G allele %	2/7/7 56.2	13/10/3 50	0.69
TPH2 rs4570625 −709 G > T	G=0.49 T=0.51 p =0.18	GG/GT/TT G allele %	3/11/2 87.5	4/16/6 76.9	0.69

p Values by the chi-square test

^aHardy-Weinberg equilibrium (HWE) of allele frequencies at individual loci was assessed by comparing the observed and expected genotype frequencies.