Fig. 4.

Vascular morphology metrics were quantified from speckle variance OCT projection images for Balb/c (n = 4) and FVB (n = 3) mice. FVB mice showed increased (A) vessel area density and (B) vessel length fraction at day 7 and subsequent time points post-surgery in the ischemic adductor region relative to Balb/c mice (*p<0.05 between strains). Balb/c mice also showed a decrease in both parameters between days 7 and 19 (p<0.05), while vessel area density and length fraction increased for FVB mice between days 3 and 7 and days 3 and 14, respectively (p<0.05). (C) Significant differences in the length of vasculature within a given range of vessel diameters were also detected (*p<0.05 for indicated range of diameters). The last imaging time point was day 19 for Balb/c mice and day 21 for FVB mice.