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. Author manuscript; available in PMC: 2015 Jan 7.
Published in final edited form as: Neuron. 2014 Nov 5;84(3):608–622. doi: 10.1016/j.neuron.2014.10.038

Figure 1.

Figure 1

PET amyloid imaging with 11C-PiB. Left: Representative PET images from three older individuals: Clinically normal older individual without evidence of elevated Aβ accumulation (CN Aβ−), Clinically normal older individual with elevated Aβ accumulation (CN Aβ+) and patient with AD dementia with very elevated Aβ accumulation (AD Aβ+) in frontal and parietal heteromodal cortices Right: Scattergram of PiB distribution value ratios (DVR) by diagnostic group: Harvard Aging Brain Study Clinically normal older individuals (HABS CN), Mild Cognitive Impairment (MCI), and AD dementia. Approximately 30% of HABS CN demonstrate elevated Aβ accumulation in the range of MCI and AD dementia Aβ+.