Skip to main content
. Author manuscript; available in PMC: 2015 Jan 7.
Published in final edited form as: Neuron. 2014 Nov 5;84(3):608–622. doi: 10.1016/j.neuron.2014.10.038

Figure 5.

Figure 5

Continuum of Alzheimer’s disease (AD). Cognitive trajectory of “normal aging (starting in late life) demonstrates some decline over decades with increased deterioration in very late life. Preclinical stage of AD at the asymptomatic stage initially demonstrates similar cognitive trajectory as “normal aging but in later stages of preclinical AD demonstrates increased rate of cognitive decline towards mild cognitive impairment (MCI) and dementia due to AD. The Anti-Amyloid Treatment in Asymptomatic AD (A4) Study will test an anti-amyloid interview in preclinical AD aimed at slowing the rate of cognitive decline.