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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Biochem Pharmacol. 2014 Nov 4;93(1):25–33. doi: 10.1016/j.bcp.2014.10.013

Figure 2. Synthesis of TDRL-505 analogs.

Figure 2

Reagents and conditions: (a) DIEA, DMAP, DCM, rt, 2 h, 90–100%. (b) (i) DMF, POCl3, 0 °C, 20 min, (ii) Amide, 110 °C, 2.5 h, 44–64%. (c) NaOH 10%, EtOH, 45 °C, 45 min. (d) H2N-NH2.H2O, EtOH, reflux, 1.5 h, 73–81% (over 2 steps). (e) CHCl3, reflux 1.5 h, 40–72%.