Table 1. In vitro and cellular IC₅₀ values of TDRL-505 and its analogs.

The in vitro IC₅₀ values are based on EMSA reactions as described in Methods. RPA was incubated with the above compounds at concentration range of 1–125 μM. The cellular IC₅₀ values are calculated from clonogenic survival assays as described in Methods. The cells were treated with the above compounds at a concentration range of 1–200 μM. Only four compounds were tested for cellular activity, the rest are indicated with ‘na’ meaning data not available since the experiments were not performed.

ENTRY	COMPOUND	Y	R	n	In vitro IC50 (μM)	Cellular IC50 (μM)
1	TDRL-505	p-Br	Et	1	38	>50
2	TDRL-533	p-Br	Me	1	>50	>50
3	TDRL-540	p-F	Me	1	>100	na
4	TDRL-543	p-Br	Et	2	25	50
5	TDRL-539	p-F	Me	2	>100	na
6	TDRL-534	p-Br	Me	2	35	na
7	TDRL-556	p-Br	iPr	2	43	na
8	TDRL-551	p-I	Et	2	18	25
9	TDRL-557	p-F3CO	Et	2	30	na
10	TDRL-652	m-I	Et	2	15	na
11	TDRL-617	See below			>100	na
12	TDRL-634	See below			>100	na