Table 4.
Multivariate longitudinal ordinal logistic regression analysis of body mass index following initiation of highly active antiretroviral therapy among 1177 women contributing a total of 18,698 person-visits during a total of 10,754 years of follow-up. Odds ratios represent the odds of attaining a higher BMI category.
| Characteristic | Adjusted Odds Ratio | 95% Confidence Interval |
|---|---|---|
|
| ||
| Pre-HAART BMI category x Years following HAART initiation, per 5 years | ||
| Underweight (< 18.5) | ||
| Normal (18.5 to <25.0) | ||
| Overweight (25.0 to <30.0) | ||
| Obese (30.0 to <40.0) | ||
| Morbidly Obese (≥40.0) | 0.92 | 0.67, 1.25 |
|
| ||
| ARV discontinued at visit | ||
| Yes | 0.66 | 0.57, 0.76 |
| No | Ref | Ref |
|
| ||
| Cumulative NRTI-years, per year | 0.97 | 0.95, 0.99 |
|
| ||
| Cumulative PI-years, per year | 1.06 | 1.04, 1.08 |
|
| ||
| Cumulative NNRTI-years, per year | 1.05 | 1.01, 1.08 |
|
| ||
| Enrollment Period | ||
| 1994–1995 | 0.66 | 0.26, 1.68 |
| 2001–2002 | Ref | Ref |
|
| ||
| Age at HAART initiationa, per 5 years | 0.89 | 0.75, 1.05 |
|
| ||
| Race/Ethnicity | ||
| Hispanic | 0.80 | 0.41, 1.54 |
| White/Other | 0.20 | 0.10, 0.42 |
| African-American | Ref | Ref |
|
| ||
| Alcohol use | ||
| ≥ 3 drinks/week | 0.87 | 0.75, 1.00 |
| <3 drinks/week | Ref | Ref |
|
| ||
| Cigarette smoking | ||
| Current | 0.58 | 0.37, 0.91 |
| Former | 1.17 | 0.75, 1.84 |
| Never | Ref | Ref |
|
| ||
| Marijuana use since last visit | ||
| Yes | 0.57 | 0.49, 0.67 |
| No | Ref | Ref |
|
| ||
| Injection drug, heroin, cocaine, or crack usesince last visit | ||
| Yes | 0.32 | 0.26, 0.38 |
| No | Ref | Ref |
|
| ||
| Quality of life, per 10 units | 1.00 | 0.97, 1.03 |
|
| ||
| Depressive symptomatology | ||
| CESD ≥ 16 | 0.89 | 0.80, 0.99 |
| CESD < 16 | Ref | Ref |
|
| ||
| Highest education level attained | ||
| Graduated college or higher | 0.31 | 0.10, 0.93 |
| Some college | 0.95 | 0.46, 1.93 |
| Completed high school | 1.53 | 0.79, 2.96 |
| Did not complete high school | Ref | Ref |
|
| ||
| History of AIDS | ||
| Yes | 0.80 | 0.66, 0.96 |
| No | Ref | Ref |
|
| ||
| CD4 cell count (cells/mm3) | ||
| <100 | 0.24 | 0.19, 0.30 |
| 100–<200 | 0.53 | 0.45, 0.63 |
| 200–<500 | 0.73 | 0.66, 0.82 |
| ≥ 500 | Ref | Ref |
|
| ||
| HIV RNAcopies/ml, per log,10 | 0.93 | 0.89, 0.97 |
HAART, highly active anti retro viral therapy; NRTI, nucleoside reverse transcriptase inhibitory; PI, protease inhibitor; NNRTI, non-nucleoside reverse transcriptase inhibitor
a
Age treated as time-invariant whose value is determined at the first visit at which highly active anti retro viral therapy was reported.