Table 1. Nongluten Protein Types Identified as Targets of IgG and/or IgA Antibody Reactivity in Patients with Celiac Disease or Dermatitis Herpetiformis.a.
protein groupb | number of reactive spots in group | protein typec | total number of patient sera with reactivity to spots in group (n = 20)c | number of celiac disease sera with reactivity to spots in group (n = 14)c | number of dermatitis herpetiformis sera with reactivity to spots in group (n = 6)c |
---|---|---|---|---|---|
1 | 7 | serpin | 15 | 9 | 6 |
2 | 5 | purinin | 13 | 10 | 3 |
3 | 9 | α-amylase/protease inhibitor | 12 | 7 | 5 |
4 | 4 | globulin | 8 | 5 | 3 |
5 | 3 | farinin | 7 | 6 | 1 |
Five distinct protein groups were identified as the main targets of the antibody response through comparison of the positions of the reactive proteins with a proteomic map of Butte 86 flour: serpins, purinins, α-amylase/protease inhibitors, globulins, and farinins.
Numbers refer to the specific immunoreactive protein groups, as marked in Figure 3A.
Number of sera found to have IgG and/or IgA antibody reactivity to spots in each protein type group, as described in the Materials and Methods section.