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The pituitary tumor exhibits diffuse weak positivity for ACTH and diffuse strong positivity for low-molecular-weight keratins identified by the Cam 5.2 antibody, consistent with a sparsely granulated corticotrope adenoma. AIP immunoreactivity is not lost, but rather shows diffuse staining. The Ki67 labeling index is relatively high for a pituitary tumor at 8–10%.
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