Semiquantitative scoring analysis of the distribution of the collagen lesions in the trabecular meshwork of Cyp1b1−/− mice. Cyp1b1−/− mice presented significantly higher median scores than wild-type mice in all ages. There was a significant increase in median score between 2- and 3-week-old and 6-week and 3-month-old Cyp1b1−/− mice. (n=42 [3/group/age], Wilcoxon–Mann–Whitney, Median ± range, *differences between Cyp1b1−/− and wild-type, p=0.002; ** differences between Cyp1b1−/− mice, p=0.005). w= week, m= month, WT = wild-type.