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. 2013 Jun 26;33(9):1386–1397. doi: 10.1111/liv.12231

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© 2013 The Authors. Liver International published by John Wiley & Sons Ltd

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Fig 1 — Thrombospondin 1 (TSP1) induced LSEC defenestration. (A) SEM images of LSEC after treatment with different doses (0 ng/ml, 10 ng/ml and 100 ng/ml) of TSP1 for 12 h. Scale bars represent 1 μm. White asterisks (*) indicate fenestrae or clusters of fenestrae (sieve plates). (B) Porosity/μm² (black bars, represent fenestrae area) and Fenestrae number/μm² (white bars, represent the absolute number of fenestrae) observed in LSEC after treatment with different doses of TSP1 (* represents P < 0.05 with Student's t-test).