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. 2015 Jan 7;5:762. doi: 10.3389/fmicb.2014.00762

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Copyright © 2015 van de Veerdonk, Gresnigt, Oosting, van der Meer, Joosten, Netea and Dinarello.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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hIL-37Tg mice are highly susceptible to disseminated C. albicans infection. (A) Survival of hIL-37Tg mice and WT mice intravenously infected with live C. albicans yeast (1 × 10e6 CFU). (B) hIL-37Tg mice and WT mice were infected i.v. with C. albicans blastoconidia (5 × 10e5 CFU/mouse). Subgroups of animals (a total of nine mice/group/time point, in two separate experiments) were killed on day 7 of infection, and fungal outgrowth was assessed in the kidneys. (C) Histology representing the accumulation of C. albicans hyphae (fungal ball) in the pyelum of hIL-37Tg mice. Arrows point to the edge of the fungal ball present in the pyelum of the kidney (A). Survival was assessed daily for 2 weeks. (n = 10/group; B) Mann–Whitney U-test, *p< 0.05.