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. 2014 Jul 9;32(4):170–177. doi: 10.1111/1755-5922.12078

Figure 3.

Figure 3

Effects of sotalol and ranolazine on APD90 dispersion upon transient low K. (A) Sotalol alone or in combination with 5 μmol/L ranolazine significantly increased APD90 dispersion upon transient low K (P < 0.05 vs. normal K). (B) Sotalol increased APD90 dispersion compared with vehicle, whereas 5 μmol/L ranolazine did not (n = 5 each, P < 0.05). (C) Sotalol alone or in combination with 10 μmol/L ranolazine significantly increased APD90 dispersion upon transient low K (P < 0.05 vs. normal K). (D) Sotalol increased APD90 dispersion compared with vehicle which could be significantly reduced by addition of 10 μmol/L ranolazine (n = 5 each, P < 0.05). P < 0.05: *vehicle versus sot+ran, #vehicle versus sot, and §sot+ran versus sot.