Table 1.
Non-compartmental and compartmental parameters of levofloxacin following intravenous infusion of levofloxacin 750 mg in healthy Chinese volunteers (n = 9, Mean ± SD)
| Non-compartmental | Compartmental | |||||
|---|---|---|---|---|---|---|
| Parameter | Single-dose PK | Multiple-dose PK | Parameter | Single-dose PK | Multiple-dose PK | |
| First Dose | Last Dose | |||||
| Cmax (μg/mL) | 14·9 ± 1·48 | 17·7 ± 4·22 | 13·3 ± 2·77c | T1/2,α (h) | 1·02 ± 0·323 | 0·305 ± 0·0473e |
| AUC0–24 h (μg·h/mL) | 73·3 ± 10·7 | 90·1 ± 11·9b | 94·1 ± 15·2b | T1/2,β (h) | 7·19 ± 0·503 | 7·22 ± 0·783 |
| AUC0–72 h (μg·h/mL) | 80·0 ± 12·5 | – | 103·7 ± 17·9 | K12 (1/h) | 0·220 ± 0·120 | 1·26 ± 0·336e |
| AUC0–∞ (μg·h/mL) | 80·1 ± 12·5 | 99·3 ± 13·7b | 104 ± 18·0b | K21 (1/h) | 0·465 ± 0·119 | 0·897 ± 0·237e |
| T1/2 (h) | 7·75 ± 0·591 | 7·52 ± 0·656 | 6·91 ± 0·806a,d | T1/2,Ke(h) | 4·62 ± 0·655 | 2·82 ± 0·854e |
| CLt (L/h) | 9·58 ± 1·62 | 8·46 ± 1·10 | 8·27 ± 1·31 | CL (L/h) | 10·2 ± 1·89 | 7·84 ± 1·10e |
| CLr (L/h) | 8·17 ± 1·28 | 6·40 ± 0·972b | 6·85 ± 1·06a | Q (L/h) | 13·8 ± 5·60 | 37·2 ± 6·05e |
| Vd (L) | 107·3 ± 20·7 | 91·3 ± 9·32 | 81·7 ± 10·5b, d | V1 (L) | 67·8 ± 13·2 | 31·6 ± 9·68e |
| MRT0–∞ (h) | 9·18 ± 0·786 | 9·72 ± 1·04 | 10·0 ± 0·97 | V2 (L) | 29·2 ± 7·61 | 43·4 ± 9·97e |
a
P < 0·05.
b
P < 0·01 vs. single-dose PK (non-compartmental parameter).
c
P < 0·05.
d
P < 0·01 vs. multiple-dose PK (first dose, non-compartmental parameter).
e
P < 0·01 vs. single-dose PK (compartmental parameter); the duration of levofloxacin infusion was 1·5 h.
The dosing regimen for the multiple-dose PK study was q24 h × 7 days.