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Generation of ROS/RNS driven by Helicobacter pylori infection regulates the redox-sensative signal molecues which leads to enhancement of snail and DNMTs. expression. Snail recruits DNMTs and induces aberrant methylation of CpG islands located in the promoter region of genes encoding cellular signal molecules such as E-cadherin or p14ARF, etc. ROS, reactive oxygen species; RNS, reactive nitrogen species; DNMTs, DNA methyltransferases.
