Table 3.
Regression analysis of predictors for moderate/severe disease
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| Odds ratio | 95% CI | Odds ratio | 95% CI | |
| Age | 1.047* | 1.004–1.092 | 1.029 | 0.980–1.080 |
| Sex | 1.000 | 0.334–2.991 | – | – |
| PUUV RNA levela in plasma | 1.099 | 0.816–1.479 | – | – |
| PUUV-specific IgM titrea in serum | 1.167 | 0.527–2.582 | – | – |
| PUUV-specific IgA titrea in serum | 1.042 | 0.579–1.874 | – | – |
| PUUV-specific IgG titrea in serum | 0.588* | 0.376–0.920 | 0.442** | 0.245–0.798 |
| White blood cell count | 1.369*** | 1.145–1.639 | 1.418*** | 1.168–1.722 |
| Day of disease when the sample was collected | 0.914c | 0.755–1.107c | – | – |
| 0.916d | 0.703–1.194d | – | – | |
| 0.901e | 0.694–1.171e | – | – | |
Levels were measured in each patient's first available sample.
Bold text indicate significance
*
p <0.05
**
p <0.01
***
p <0.001.
a
Log scale (10 log).
b
Scale: 1 unit = 1 × 109/L.
c
Plasma sample for Puumala hantavirus (PUUV) RNA level. Subdivision into time intervals 0–3, 4–7 and 8–11 days was not significantly associated with moderate/severe illness (p 0.12, p 0.454 and p 0.747, respectively). Confidence intervals not applicable because of small samples sizes.
d
Serum sample for antibody titre.
e
Serum sample for white blood cell count.