Figure 2.

Genomic and transcriptomic differences between clone 6A and 11C.A. Distribution of the CGH microarray signal plotted as log₂ ratios between clones 6A and 11C over the 14 P. falciparum chromosomes with red peaks representing the statistically significant CNPs. Red lines with log₂ ratios > 0 indicates higher copy (above x-axis) number and log₂ ratios < 0 (below x-axis) indicate lower copy number in clone 6A relative to 11C. Genes associated with the CNPs are shown in the grey boxes. The double asterisk (**) indicates that the CNP is detected at the non-coding 5′ region of the gene instead of within the coding sequence of the gene.B. Heat maps showing the mean-centred microarray log₂ expression ratios of the 4478 P. falciparum genes ordered by fast fourier transformation over the 48 h IDC for clones 6A and 11C.C. Heat map showing the log₂ expression ratios of the 23 differentially expressed (DE) genes detected by Statistical Analysis of Microarrays (SAM) with FDR < 5% over the IDC [depicted by hours post invasion (hpi)]. The DE genes with corresponding detected CNPs are indicated with blue or yellow symbols. R: ring; T: trophozoite; S: schizont.