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. 2014 Sep 8;36(9):421–427. doi: 10.1111/pim.12080

Table 1.

Schistosoma mansoni-induced pathological outcomes in cell-specific IL-4Rα-deficient mice

Mouse strain IL-4Rα cell specificity Mortality AST level Fibrosis LPS level Reference
IL-4Rα−/− All cells + + − + 36
LysMcreIL-4Rα−/lox Macrophages and neutrophils + + ± + 36
CD4+IL-4Rα−/lox CD4+ T cells − + + − 40
iLckcreIL-4Rα−/lox Pan-T cells + + ± ± 41
SM-MHCcreIl-4Rα−/lox Smooth muscle cells + NM ± ± 42

AST, aspartate transaminase (indicator of hepatocellular damage); LPS, lipopolysaccharides (indicator of gut destruction); +, increased compared to littermate control mice; −, decreased compared to littermate control mice; ±, equivalent to littermate control mice; NM, not measured.