Fig. 6.

Therapeutic effects of JTE-052 on collagen-induced arthritis in a rat model. Rats with clinical signs of joint inflammation were randomized (n = 10) and orally administered vehicle, JTE-052 (0.1, 1, or 10 mg/kg), or MTX (0.3 mg/kg) once daily for 2 weeks from day 15. The hind paw volume (a) and body weight (b) were measured periodically. Images of hematoxylin and eosin staining (c) and radiographs of hindlimbs (e) are shown. Histological change (d) and radiographical change (f) were scored. The results are expressed as mean ± SD. *p < 0.05, **p < 0.01, versus vehicle by Dunnett’s test. ^# p < 0.05, ^## p < 0.01, versus vehicle by the Steel test