Table 1.

IC₅₀ and Ki values of JAK inhibitors in enzyme assays

Compounds		JAK1	JAK2	JAK3	Tyk2
JTE-052	IC50 (nM)	2.8 ± 0.6	2.6 ± 0.2	13 ± 0	58 ± 9
	Ki (nM)	2.1 ± 0.3	1.7 ± 0.0	5.5 ± 0.3	14 ± 1
Tofacitinib	Ki (nM)	2.0 ± 0.4	1.3 ± 0.0	0.74 ± 0.01	20 ± 2
Ruxolitinib	Ki (nM)	1.3 ± 0.3	0.36 ± 0.10	7.0 ± 1.9	1.6 ± 0.1

Values are mean ± SEM. Three independent experiments were performed