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. 2014 Sep 26;66(10):2762–2772. doi: 10.1002/art.38770

Figure 5.

Figure 5

Expression of the neutrophil marker Ly-6G in the joints of mice with antigen-induced arthritis. Arthritis was induced in WT and DR3−/− mice, and the joints were prepared, sectioned, and stained as described in Materials and Methods. A, Representative low-magnification photomicrographs of joint sections from WT and DR3−/− mice stained for Ly-6G, 3 days after induction of arthritis. Arrowheads highlight staining in the synovial membrane (red) or fat pad (yellow). B, Quantification of Ly-6G expression in the joints of WT and DR3−/− mice. C, Representative high-magnification photomicrographs of fat pad sections from the joints of WT and DR3−/− mice. Arrowheads highlight staining of infiltrating cells. D, Quantification of Ly-6G expression in fat pad and synovial membrane sections obtained from the right knees of WT and DR3−/− mice. Bars in A and C = 60 μm. In B and D, each data point represents a single mouse; horizontal lines show the mean. P values were determined by Mann-Whitney U test. See Figure 1 for definitions.